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Companies/Upstream Bio, Inc.
Company profile

Upstream Bio, Inc.

NASDAQ: UPB · Healthcare · Biotechnology
PublicHQ Waltham, MA · MiddlesexCIK 0002022626Reports USD
#754 of 1,394 Healthcare companies by revenue68th-percentile growth
EA Score
45D
FH 48DQ 41GM —SS 44
v0.1 · 55/100 weight · provisional
↑ balance-sheet leverage, Altman-Z · ↓ listing tenure, disclosure history
Methodology →
Revenue TTM
$3.3M
Rev growth YoY (TTM)
+44.7%
Net income (FY)
-$143.4M
Employees
52
Market cap
$408.7M
OverviewFinancialsSegmentsFilingsESGPeople & Places

Financials — latest annual

SEC EDGAR · USD-normalized
ConceptUSDNativeFY
Revenue$2.9M$2.9M2025
Net income-$143.4M-$143.4M2025
Operating income-$160.4M-$160.4M2025
Total assets$353.8M$353.8M2025
Liabilities$14.0M$14.0M2025
Equity$339.8M$339.8M2025

Revenue trend

FY2024 – FY2025 · USD
$2.4M
FY24
$2.4M
FY24
$2.9M
FY25

Revenue by segment

No segmentation disclosed for this filer. n/a

The read

Upstream Bio, Inc. booked $2.9M in FY2025 revenue, growing 20% year over year — faster than most Healthcare companies we track, at a -5026.0% net margin.

Peers · Healthcare
DiaMedica Therapeutics Inc.35DPureTech Health plc——Aquestive Therapeutics, Inc.47DOrthofix Medical Inc.75B+
Neighbors
Middlesex →
GE Vernova Inc.$38.1B63CThermo Fisher Scientific Inc.$44.6B86AAnalog Devices, Inc.$11.0B87AThe TJX Companies, Inc.$60.4B85ABoston Scientific Corporation$20.1B88AAlnylam Pharmaceuticals, Inc.$3.7B79B+
Key facts
CEOE. Rand Sutherland
SectorHealthcare
IndustryBiotechnology
HeadquartersWaltham, MA
ExchangeNASDAQ: UPB
Employees52
IPO date2024-10-11
Latest filings
8-K2026-06-108-K2026-05-1310-Q2026-05-13DEF 14A2026-04-1610-K2026-03-268-K2026-03-268-K2026-03-268-K2026-02-11
Financials: SEC EDGAR (XBRL), USD-normalized per IAS 21 · TTM/quarterly + segments: FMP from filed disclosures · Filings: EDGAR submissions. County headcount and EA Score are in progress — see docs/DATA_GAPS.md.
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